If you were to make a new thread to discuss the comic, we'd ask that you post a warning in the thread topic to say that the thread may contain mature discussions and isn't for those under-aged.
If you were discussing this sort of thing in another thread (for example, a Menewsha Nations thread), it would be courtesy to post anything too questionable under a spoiler or give warning that those who just stumble upon the thread that you're discussing a mature topic. But it's not actually required.
The PG-13 blanket mostly applies to what is allowed to be linked to, embedded (in the case of video or pictures), and role-played/done over PMs. Discussions can be mature as long as they are properly labeled in the case of discussion threads about the subject or not spammed in other threads.
Of course, there is some discretion involved on the part of the staff. I don't think we'd allow a thread about what your favorite porn site is, for example. But discussion about a mature webcomic should be fine.