My two favorites are probably "The Nerdist" and "You've Got Dead On You" (which is actually more of a old time radio show done through a podcast but it's hilarious nonetheless.)
It's a bit egocentric since I'm the deej, but I'm still pretty fond of Lamb Sits Down at B-Town (which is downloadable in 20 minute segs @ Teeny Turtle's Weird World of Whatnots )