*cracks knuckles in preparation for a type fest*
1. Racism ((Any "ism" really--they're all pointless.))
2. People who refuse to let people live their lives however they chose
3. Frequent or constant over-indulgence of any kind
4. People who don't watch their kids and make sure they behave
5. People who talk on their cell phones when checking out, at the movies, in the library, or are just being really obnoxious while on the phone.
6. Stubborn ignorance--refusal of enlightenment is the same thing
7. Excessive bad grammar/spelling
8. Animal, child, and old people abusers
9. Drug dealers
10. Dirty cops

I'm limiting myself to ten.