Scientifically made werewolf would be awesome. If we did that, I could see it being either a big city or a small town. The city for the big research firms, and the town if they wanted to keep it a secret. So maybe we could have it start out in the city, like they did all the genetic mutation in the labs there and moved everything to a small town, that's still not too far away once they didn't need all the heavy duty machines?