In Silent Hill Homecoming I have to restart sometimes because of the sucky controls. I sometimes use a serum, a rare health item that replenishes all your health, by accident. There's no way to cancel the option of using an item if it's highlighted, so if you move your control stick while in the menu and that's all you have in your inventory, you're screwed.
Eh, it's still a cool game to play though. Not like the other Silent Hills, but I still like it.